SHBG CLIA Kit for Human(Homo sapiens) | EIAab.comSHBG CLIA Kit for Human(Homo sapiens)

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Index > Protein center > SHBG(Gene name) > Human

SHBG (Gene name),

Sex hormone-binding globulin (Protein name ), SHBG_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SHBG;

Protein name:

Sex hormone-binding globulin(SHBG);

Alternative:

Testis-specific androgen-binding protein(ABP);Sex steroid-binding protein(SBP);Testosterone-estrogen-binding globulin;Testosterone-estradiol-binding globulin(TeBG);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Subcellular Location:

Secreted In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.

Protein Attributes:

Sequence length:

402

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

402:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P04278

UniGene:

Hs.632235

STRING:

9606.ENSP00000369816

MIM:

182205

KEGG:

hsa:6462

Pfam:

PF00054

String:

P04278

Uniprot:

P04278

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ELISA Kit for Human SHBG

Cat.:

E0396h

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Packing:

96T

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ELISA Kit for Human SHBG

Cat.:

E0396r

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Packing:

96T

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ELISA Kit for Human SHBG

Cat.:

E0396m

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Packing:

96T

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ELISA Kit for Human SHBG

MSDS:

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CLIA Kit for Human SHBG

MSDS:

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CLIA Kit for Human SHBG

Cat.:

U0396r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human SHBG

Cat.:

U0396h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human SHBG

Cat.:

U0396m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human SHBG

Cat.:

P0396Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human SHBG

Cat.:

P0396Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human SHBG

Cat.:

P0396Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human SHBG

Protein for Human SHBG

Cat.:

R0396h

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis."
Gershagen S. , Lundwall A. , Fernlund P.
Nucleic Acids Res.17:9245-9258(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
tissue: Testis.
2.

"The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs."
Hammond G.L. , Underhill D.A. , Rykse H.M. , Smith C.L.
Mol. Endocrinol.3:1869-1876(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING
tissue: Testis.
3.

"PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."
Jin P. , Fu G.K. , Wilson A.D. , Yang J. , Chien D. , Hawkins P.R. , Au-Young J. , Stuve L.L.
Genomics83:566-571(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
4.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Liver.
6.

"The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain."
Hammond G.L. , Underhill D.A. , Smith C.L. , Goping I.S. , Harley M.J. , Musto N.A. , Cheng C.Y. , Bardin C.W.
FEBS Lett.215:100-104(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-402 (ISOFORM 1)
tissue: Liver.
7.

"Human sex hormone-binding globulin gene transcript expression in liver, prostate, breast, testis, and brain- multiple promoters and complex alternative splicing."
Kahn S.M. , Nakhla A.M. , Hryb D.J. , Rosner W. , Romas N.A.
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-402 (ISOFORM 4)
tissue: Liver.
8.

"A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S."
Gershagen S. , Fernlund P. , Lundwall A.
FEBS Lett.220:129-135(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-402 (ISOFORM 1)
tissue: Liver.
9.

"Characterization of a cDNA coding for sex steroid-binding protein of human plasma."
Que B.G. , Petra P.H.
FEBS Lett.219:405-409(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-402 (ISOFORM 1)
tissue: Liver.
10.

"Physicochemical characteristics of human sex hormone binding globulin: evidence for two identical subunits."
Hammond G.L. , Robinson P.A. , Sugino H. , Ward D.N. , Finne J.
J. Steroid Biochem.24:815-824(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-54
11.

"Amino acid sequence of the sex steroid binding protein of human blood plasma."
Walsh K.A. , Titani K. , Takio K. , Kumar S. , Hayes R. , Petra P.H.
Biochemistry25:7584-7590(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-402
12.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-380
tissue: Plasma.
13.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-380
tissue: Liver.
14.

"Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain."
Power S.G.A. , Bocchinfuso W.P. , Pallesen M. , Warmels-Rodenhiser S. , Van Baelen H. , Hammond G.L.
J. Clin. Endocrinol. Metab.75:1066-1070(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-356;CHARACTERIZATION OF VARIANT ASN-356;GLYCOSYLATION
15.

"Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain."
Grishkovskaya I. , Avvakumov G.V. , Sklenar G. , Dales D. , Hammond G.L. , Muller Y.A.
EMBO J.19:504-512(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 42-211
16.

"Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation."
Grishkovskaya I. , Avvakumov G.V. , Hammond G.L. , Catalano M.G. , Muller Y.A.
J. Biol. Chem.277:32086-32093(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 42-218
17.

"Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjects."
Hardy D.O. , Carino C. , Catterall J.F. , Larrea F.
J. Clin. Endocrinol. Metab.80:1253-1256(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-356
18.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-25 AND ASN-356
19.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM

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